This learning-centered course design for Interpretation of Science and Technology is based on both theoretical and experimental study. It is mainly divided into two levels: intermediate and advanced, under the themes of shopping, catering, reception, tourism and ceremonial speech, exhibition introduction, dialogues & interviews, business negotiation respectively. The course attaches much importance to basic interpretation skills as well as scientific terms and knowledge. Each lesson includes basic knowledge and skills introduction, on site interpretation demonstration, situational practice, and teacher student assessment. Formative assessment is applied in this course to enhance students’ learning autonomy. Therefore, as for the final score, all self-assessment, peer-assessment as well as teacher assessment of the in class performance, after class practice and final exam representation will be taken into account.