“Mechanical structure design” is one of the advanced and compulsory courses for Mechanical Design and Manufacture & Automation. As it involves a lot of professional knowledge, it is very difficult for students to learn. In the teaching process, a combination of case teaching, experiments and curriculum design is adopted. Through the study of the course, the students can master structural design principles and steps of drive components, and form initial ideas of the mechanical structure design and thus have a certain ability to design independently.