To enhance the industry-university-research cooperation in industrial enterprises is both an important way for training applied talents and a good plan for the technological development of the enterprise itself. Currently, there are a lot of researches on industrial-enterprise-cooperation from the university-oriented perspective. This paper attempts to explore this issue from the enterprise-oriented perspective. It can be expected that not only “complementariness” and “resource sharing” but also “cost saving” and “risking sharing” effect can be achieved, and that ultimately the company’s overall technological level can be raised. This paper proposes, in the process of project management, a centralized management department of industry-university research through project management measures at the three levels of “setting management”, “processing management”, and “acceptance management” in the hope of strengthening management and ensuring an effective industry university research cooperation.