Training and improving the practical and innovative ability of college students are an important goal of experimental teaching.It is an objective requirement of modern higher education, and also an inherent requirement of the Education Program of Outstanding Engineers.Aiming at the teaching goal of Power Engineering Measurement and Control Technology experiment in University of Shanghai for Science and Technology, the thermocouple calibration experiment is designed as a thermocouple synthesis experiment, which integrates thermocouple manufacture, calibration and automatic acquisition.It is shown that the reform and practice of synthetical experiment of thermocouple can significantly improve the teaching quality, strengthen the understanding and application of the comprehensive knowledge, and exercise students' ability to solve problems.