Based on the practice of teaching advanced mathematics and medical advanced mathematics,a project-driven,problem-oriented PBL teaching model is constructed in the teaching process of medical advanced mathematics.The organic combination of theory and practice is realized by setting up the case database related to majors and introducing experiments into mathematical teaching.It is found that this type of inquiry teaching model can help to cultivate students’ creative thinking and self-learning ability,to improve students’ ability to solve medical practical problems with mathematical knowledge,as well as to promote students’ innovation ability and sense.