Based on the typical SIR model (susceptible infected recovered model) and related research in complex networks, the USCIR model (unsusceptible susceptible contracted infected recovered model) is proposed, and the features of the university network public opinion are analyzed within the framework of the model. The university network public opinion is characterized by the following features: being in an obvious small-world and scale-free, the coexisting homogeneity and heterogeneity of multi-attribute nodes, different structures of public opinion network on each platform, and presenting self-organization and game behavior between nodes. Based on the USCIR model, relevant strategies and suggestions are proposed for guiding university network public opinion.