Marxism regards system as a way related to the holistic existence of things, which provides a comprehensive thinking approach and practical method for integrating moral value education into course teaching. In the realm of systematic epistemology, we have grasped the holistic nature of the systemic moral value education in curriculum design, and gain a scientific understanding of relationships such as complementarity and interaction, time and space, sharing and connection, coupling and collaboration, symbiosis and openness. In terms of systematic practice, we should adhere to the coupling nature of moral value education system in curriculum. Through content coordination, subject collaboration, spatial and institutional cooperation, we can achieve organic integration of internal elements within the moral value education system in curriculum, as well as its compatibility with the external systems. In terms of system methodology, we should embed moral value education into courses with effective value embedding, structural embedding, and cultural embedding. In terms of the system value theory, we should grasp the dialectical nature of moral value education in curriculum system so as to achieve the dialectical unity of purposefulness and regularity, problem orientation and goal orientation, seeking common ground while reserving differences.